2024
Peptidoglycan synthesis drives a single population of septal cell wall synthases during division in Bacillus subtilis KD Whitley, J Grimshaw, DM Roberts, E Karinou, PJ Stansfeld, S Holden. Nature Microbiology (in press)
2023
A one-track model for spatiotemporal coordination of Bacillus subtilis septal cell wall synthesis KD Whitley, J Grimshaw, E Karinou, PJ Stanfeld, S Holden. bioRxiv
Molecular motor tug-of-war regulates elongasome cell wall synthesis dynamics in Bacillus subtilis S Middlemiss, DM Roberts, J Grimshaw, JM Edwards, Z Sun, KD Whitley, T Blu, H Strahl, S Holden. bioRxiv
Self-organisation of mortal filaments: the role of FtsZ treadmilling in bacterial division ring formation C Vanhille-Campos, KD Whitley, P Radler, M Loose, S Holden, A Šarić. bioRxiv
2022
High-resolution imaging of bacterial spatial organisation with Vertical Cell Imaging by Nanostructured Immobilisation (VerCINI) KD Whitley, S Middlemiss, C Jukes, C Dekker, S Holden. Nature Protocols 17, 847-869
2021
Kinetic and structural mechanism for DNA unwinding by a non-hexameric helicase SP Carney*, W Ma*, KD Whitley, H Jia, TM Lohman, Z Luthey-Schulten, YR Chemla. Nature Communications 12, 7015
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in Bacillus subtilis cell division KD Whitley*, C Jukes*, N Tregidgo, E Karinou, P Almada, Y Cesbron, R Henriques, C Dekker & S Holden. Nature Communications 12, 2448
2019
Regulation of Rep helicase unwinding by an auto-inhibitory subdomain MA Makurath, KD Whitley, B Nguyen, TM Lohman, YR Chemla. Nucleic Acids Research 47 (5), 2523-2532
2018
Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase W Ma, KD Whitley, YR Chemla, Z Luthey-Schulten, K Schulten. eLife 7, e34186
Ultrashort nucleic acid duplexes exhibit long wormlike chain behavior with force-dependent edge effects KD Whitley, MJ Comstock, YR Chemla. Physical Review Letters 120 (6), 068102
2017
Single-molecule studies of mechanical and helicase-catalyzed disruption of nucleic acid duplexes KD Whitley University of Illinois at Urbana-Champaign (PhD Thesis)
Elasticity of the transition state for oligonucleotide hybridization KD Whitley, MJ Comstock, YR Chemla. Nucleic Acids Research 45 (2), 547-555
High-resolution “Fleezers”: Dual-trap optical tweezers combined with single-molecule fluorescence detection KD Whitley, MJ Comstock, YR Chemla. Optical Tweezers, 183-256
High-resolution optical tweezers combined with single-molecule confocal microscopy KD Whitley, MJ Comstock, YR Chemla. Methods in Enzymology 582, 137-169
2015
Direct observation of structure-function relationship in a nucleic acid–processing enzyme MJ Comstock, KD Whitley, H Jia, J Sokoloski, TM Lohman, T Ha. Science 348 (6232), 352-354
2012
Tyrosine triad at the interface between the Rieske iron–sulfur protein, cytochrome c1 and cytochrome c2 in the bc1 complex of Rhodobacter capsulatus JA Kyndt, JC Fitch, RE Berry, MC Stewart, K Whitley, TE Meyer, FA Walker, MA Cusanovich. Biochimica et Biophysica Acta – Bioenergetics 1817 (5), 811-818